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| Nephrogenic Diabetes Insipidus | Nephrogenic Diabetes Insipidus Treatment
The objective of treatment is to control fluid levels in the body.
All cases should be treated with constantly high fluid intake. The volume of fluids ingested should roughly equal the volume of urine made.
Reduction or discontinuation of medicines that may provoke nephrogenic DI may improve symptoms.
Hydrochlorothiazide may improve symptoms. This may be used alone or in combination with other medicines, including indomethacin. Although this drug is a diuretic (these medications are usually used to increase urine output), in certain cases hydrochlorothiazide can truly decrease urine output for people with nephrogenic DI.
This medicine works by causing sodium and water to be excreted in the early part of the renal tubules (the proximal tubules).
This leaves less fluid available for the late portion of the kidney (distal tubule) to excrete -- this is the portion affected by nephrogenic DI – and therefore it restricts the full volume of urine that can be excreted.
Nephrogenic Diabetes Insipidus Prognosis
Unfortunately, congenital nephrogenic DI is a chronic conditionb which requires lifelong treatment. Acquired nephrogenic DI may be short-term or long-term.
Possible Nephrogenic Diabetes Insipidus Complications
- Severe dehydration, shock (if inadequate fluid intake)
- Hypernatremia (high blood sodium)
- Dilation of the ureters and bladder
Time to Contact a Medical Professional
You should call your health care provider if symptoms indicate diabetes insipidus may be present.
Nephrogenic Diabetes Insipidus Prevention
Unfortunately, there is no acknowledged prevention for congenital nephrogenic diabetes insipidus. Treatment of causative disorders may put off some cases of acquired nephrogenic DI. Medicines should only be used under the supervision of the health care provider.
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